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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AURKA All Species: 16.36
Human Site: S51 Identified Species: 24
UniProt: O14965 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14965 NP_003591.2 403 45809 S51 A Q R V L C P S N S S Q R V P
Chimpanzee Pan troglodytes XP_525364 403 45791 S51 A Q R V L C P S N S S Q R V P
Rhesus Macaque Macaca mulatta XP_001098364 471 52859 R118 A C V C L G P R E A A G R A G
Dog Lupus familis XP_853397 405 45606 S52 A Q R V L C P S N S S Q R V P
Cat Felis silvestris
Mouse Mus musculus P97477 395 44754 N51 Q R V L C P S N S Q R V P S Q
Rat Rattus norvegicus P59241 397 44856 N51 Q R V L C P S N S Q R V P P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521399 303 34973
Chicken Gallus gallus XP_425725 409 46456 S55 P Q R V L C P S N F A Q R V P
Frog Xenopus laevis Q91819 408 46443 S53 A Q R I L G P S N V P Q R V M
Zebra Danio Brachydanio rerio Q6NW76 320 36928
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VKN7 329 38282 A9 T L S R A K H A N R N H L P H
Honey Bee Apis mellifera XP_395732 327 37711 P8 M S T E L M P P P K L P P V S
Nematode Worm Caenorhab. elegans O01427 305 34731
Sea Urchin Strong. purpuratus XP_001181990 278 32048
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q683C9 282 32738
Baker's Yeast Sacchar. cerevisiae P38991 367 42927 I48 Q R N P N S K I P S P V R E K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 100 47.7 89.8 N.A. 82.6 83.6 N.A. 65.5 73.1 65.9 53.3 N.A. 38.4 53 46.6 50.6
Protein Similarity: 100 100 62.2 93 N.A. 86.8 87.3 N.A. 70.2 82.8 77.2 65.7 N.A. 57.8 67 56.3 60
P-Site Identity: 100 100 26.6 100 N.A. 0 0 N.A. 0 80 66.6 0 N.A. 6.6 20 0 0
P-Site Similarity: 100 100 40 100 N.A. 26.6 26.6 N.A. 0 86.6 73.3 0 N.A. 20 20 0 0
Percent
Protein Identity: N.A. N.A. N.A. 46.4 38.9 N.A.
Protein Similarity: N.A. N.A. N.A. 55.3 57.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 32 0 0 0 7 0 0 7 0 7 13 0 0 7 0 % A
% Cys: 0 7 0 7 13 25 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 7 0 0 0 0 7 0 0 0 0 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 13 0 0 0 0 0 7 0 0 7 % G
% His: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 7 % H
% Ile: 0 0 0 7 0 0 0 7 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 7 7 0 0 7 0 0 0 0 7 % K
% Leu: 0 7 0 13 44 0 0 0 0 0 7 0 7 0 0 % L
% Met: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 7 0 7 0 0 13 38 0 7 0 0 0 0 % N
% Pro: 7 0 0 7 0 13 44 7 13 0 13 7 19 13 25 % P
% Gln: 19 32 0 0 0 0 0 0 0 13 0 32 0 0 13 % Q
% Arg: 0 19 32 7 0 0 0 7 0 7 13 0 44 0 0 % R
% Ser: 0 7 7 0 0 7 13 32 13 25 19 0 0 7 7 % S
% Thr: 7 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 19 25 0 0 0 0 0 7 0 19 0 38 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _